Eliquis is an oral anticoagulant that inhibits the clotting factor xa. Its pharmacological action blocks the enzymatic step that converts prothrombin to thrombin. By reducing thrombin generation, the drug decreases the formation of fibrin clots. The therapeutic purpose of Eliquis is to prevent and treat venous thromboembolic events. It is used to lower the risk of stroke in patients with atrial fibrillation. The medication is absorbed in the intestine, metabolized by the liver, and eliminated primarily through the kidneys.

Apixaban sold under the brand name Eliquis is an oral medication that belongs to the class of direct factor xa inhibitors. It works by binding to factor xa, a key enzyme in the clotting cascade, which blocks the conversion of prothrombin to thrombin. By inhibiting factor xa the drug reduces the production of thrombin, limiting the formation of fibrin strands that stabilize blood clots. This action decreases the overall tendency of blood to clot, lowering the risk of thromboembolic events such as stroke. In patients with non-valvular atrial fibrillation the medication improves stroke prevention by maintaining a stable anticoagulant effect. The effect is achieved through selective inhibition of factor xa in both circulating and tissue-bound forms of the enzyme. The drug half-life is approximately 12 hours which allows dosing twice daily in many patients. Because it is eliminated primarily through the kidneys dose adjustment may be needed in patients with impaired renal function.

Eliquis can increase the risk of bleeding including nosebleeds and gum bleeding. Unexplained bruising or prolonged bleeding from cuts may occur. Some people experience nausea or stomach discomfort while taking the medication. Dizziness or headache are reported side effects. Rarely, low blood cell counts such as anemia may develop. Fatigue can be observed but is usually mild.

Eliquis may cause bleeding from cuts or internal sites such as the stomach and brain. It can also increase the risk of bruising that appears without obvious injury. Some people experience dizziness or light-headedness while taking the medication. Rarely, the drug may lead to swelling of the feet or ankles. Elevation of liver enzymes can occur, which may affect blood test results. In some cases, an allergic reaction such as rash or itching may develop. Patients with kidney problems might notice changes in urine output or color. These effects are generally mild and can be observed through routine laboratory assessments.