Zestoretic is a prescription medication that combines lisinopril and hydrochlorothiazide. It is used to treat high blood pressure in adults. The drug works by blocking the enzyme that converts angiotensin i to angiotensin ii, which helps relax blood vessels. At the same time the thiazide component promotes the excretion of sodium and water, reducing blood volume. Together these actions lower systemic vascular resistance and cardiac output, leading to a measurable drop in blood pressure. The fixed-dash combination provides a convenient way to achieve additive antihypertensive efficacy. It is taken orally once daily.

Zestoretic is a fixed combination medication that contains the ace inhibitor lisinopril and the thiazide diuretic hydrochlorothiazide. It is prescribed to treat hypertension by providing dual mechanisms that lower blood pressure more effectively than either agent alone. The ace inhibitor component blocks the conversion of angiotensin i to angiotensin ii, leading to vasodilation and reduced systemic vascular resistance. The thiazide component promotes natriuresis and diuresis by inhibiting sodium reabsorption in the distal convoluted tubule, decreasing plasma volume. Together these actions result in a synergistic reduction in arterial pressure while maintaining overall cardiovascular stability. The pharmacokinetic interaction of the two agents is characterized by complementary absorption and elimination pathways that enhance the duration of therapeutic effect without significant metabolic overlap.

Zestoretic may cause dizziness or lightheadedness especially when standing up quickly. It can also lead to a dry cough or a mild headache. Some people experience increased urination or a feeling of tiredness. Changes in blood pressure may result in low sodium or low potassium levels. It is possible to develop a rash or mild swelling in the ankles. Most side effects are temporary and improve with continued use.

Some people experience dizziness or light headedness when taking Zestoretic. Headache is another frequently reported symptom. A dry cough can occur due to the ace inhibitor component. Fatigue or unusual tiredness may be noticed. Changes in potassium levels are possible with low potassium being more common. Some patients develop a mild skin rash. Increased urination can happen as the medication affects fluid balance. Swelling of the ankles or feet is occasionally observed.