Indomethacin is a non-steroidal anti-inflammatory drug that belongs to the class of heterogeneous arylpropionic acid derivatives. It is used primarily to relieve pain and inflammation associated with conditions such as arthritis osteoarthritis and rheumatoid arthritis. The drug works by inhibiting the enzyme cyclooxygenase which is required for the synthesis of prostaglandins that mediate pain and fever. By reducing prostaglandin production Indomethacin decreases swelling and stiffness in affected joints. It also possesses antipyretic properties that help lower elevated body temperature. The medication is absorbed from the gastrointestinal tract and reaches therapeutic concentrations in the bloodstream after oral administration. Its pharmacokinetic profile includes extensive plasma protein binding and hepatic metabolism which influences its duration of action. Clinically the drug provides symptomatic control of inflammation while not altering the underlying disease progression.

Indomethacin is a nonsteroidal anti-inflammatory drug that belongs to the class of cyclooxygenase inhibitors. It is used to reduce inflammation pain and fever associated with conditions such as rheumatoid arthritis osteoarthritis and ankylosing spondylitis. The medication works by blocking the enzymes cyclooxygenase one and two which are responsible for producing prostaglandins that mediate pain and swelling. By decreasing prostaglandin synthesis it helps to alleviate the biological signals that trigger tissue inflammation and nociceptive signaling. Its pharmacokinetic profile includes rapid oral absorption with extensive protein binding and hepatic metabolism that produces inactive metabolites eliminated primarily by the kidneys. The drug's ability to cross the blood-brain barrier allows central analgesic effects while its peripheral action contributes to reduced swelling at inflamed sites. Overall Indomethacin provides therapeutic benefit through targeted inhibition of prostaglandin production that modulates both pain perception and inflammatory responses.

Indomethacin can cause stomach discomfort, nausea, and occasional heartburn. It may increase the risk of ulcers in the gastrointestinal tract. Some users experience headaches or dizziness. The medication can raise blood pressure in certain individuals. Rarely, it may affect kidney function or cause swelling in the ankles. Skin reactions such as rash or itching have been reported. Long-term use may influence liver enzyme levels.

Indomethacin can irritate the gastrointestinal lining and sometimes lead to ulcers. It might increase the risk of bleeding in the stomach or intestines. Some users experience headaches or dizziness. Fluid retention can result in swelling of the hands or feet. Elevated blood pressure has been reported in certain patients. Skin reactions such as rash or itching may occur. Occasionally, kidney function can be impaired with prolonged use. Respiratory symptoms like shortness of breath have been observed in rare cases.