Cardizem is a brand name for diltiazem, a calcium channel blocker used to treat hypertension and angina. It works by inhibiting the influx of calcium ions into cardiac and smooth muscle cells, which relaxes blood vessels and reduces heart workload. The inhibition decreases intracellular calcium concentration, leading to vasodilation and reduced myocardial oxygen demand. By lowering systemic vascular resistance, Cardizem helps lower blood pressure and improve blood flow to the heart. It also slows the heart rate by affecting the sinoatrial node, further decreasing cardiac output. The combined vasodilatory and rate-slowing effects relieve symptoms of angina and support long-term blood pressure control.

Cardizem is the brand name for diltiazem, a calcium channel blocker used to treat hypertension and certain heart rhythm disorders. The drug works by inhibiting the influx of calcium ions into cardiac and smooth muscle cells through the l-type calcium channels. This inhibition reduces the contractility of the heart muscle and relaxes the walls of blood vessels, leading to decreased blood pressure and lower cardiac workload. By decreasing the heart's oxygen demand, Cardizem also helps relieve symptoms of angina caused by reduced blood flow to the myocardium. The medication's vasodilating effect is achieved through the relaxation of arterial smooth muscle, which lowers peripheral vascular resistance. The slowed conduction of electrical impulses through the atrial septum and atrioventricular node contributes to its use in managing certain supraventricular tachycardias. Pharmacokinetically, diltiazem is absorbed orally, reaches peak plasma concentrations within one to four hours, and is metabolized primarily by the liver enzyme cyp3a4. Its active metabolites continue to exert calcium channel blocking activity, extending the drug's therapeutic effect over several hours.

Cardizem may cause dizziness or lightheadedness especially when standing up quickly. Some patients experience a slow heart rate or irregular heartbeat. Headache and flushing are also reported side effects. Swelling of the ankles or feet can occur. Fatigue or feeling unusually tired is another possible effect. These reactions are generally mild and temporary.

Cardizem may cause dizziness or lightheadedness as it lowers blood pressure. Some patients experience a slow heart rate known as bradycardia. Swelling of the ankles or feet can occur due to fluid retention. Headache and flushing are possible reactions as the medication affects blood vessels. In rare cases liver enzyme elevations may be detected during routine blood tests. These effects are generally mild and often improve with continued use.