Toradol is the brand name for the nsaid ketorolac, which is used as a short-term adjunct for moderate to severe acute pain. It belongs to the class of cyclooxygenase inhibitors that reduce the synthesis of prostaglandins responsible for inflammation and pain signaling. The drug acts by irreversibly blocking cox-1 and cox-2 enzymes in peripheral tissues, leading to decreased prostaglandin production. By lowering prostaglandin levels, ketorolac diminishes vasodilation, sensitisation of nociceptors, and the inflammatory response that amplify pain perception. Its analgesic effect is primarily central and peripheral, providing analgesia without the sedative properties associated with opioid medications. Elimination occurs chiefly through renal excretion of unchanged drug and metabolites, with a half-life that supports dosing intervals of up to six hours in clinical use.

Toradol is the brand name for the drug ketorolac tromethamine, an injectable nonsteroidal antiinflammatory medication. It belongs to the class of nsaids that inhibit the cyclooxygenase enzymes cox1 and cox2 to reduce prostaglandin synthesis. By decreasing prostaglandin production in peripheral tissues, it diminishes inflammation and the associated pain signals. The medication is primarily used for short term management of moderate to severe acute pain when opioid analgesics are not advisable. It acts centrally and peripherally by limiting the availability of prostaglandins that sensitize nociceptors. This inhibition leads to reduced vasodilation and lower levels of inflammatory mediators that contribute to swelling and discomfort. Toradol has no significant opioid activity and therefore does not provide respiratory depressant effects. Its therapeutic effect is achieved through systemic absorption after intramuscular or intravenous administration, followed by hepatic metabolism and renal excretion.

Toradol can cause gastrointestinal discomfort such as nausea or abdominal pain. It may lead to headache or dizziness in some individuals. Elevated liver enzymes have been reported during prolonged therapy. Some users experience ringing in the ears or changes in taste. Fluid retention can result in swelling of the ankles or feet. Blood pressure fluctuations including increases may occur. Rarely allergic reactions such as rash or itching can develop.

Toradol may cause stomach upset nausea headache dizziness rash and fatigue. It can also increase the risk of bleeding or bruising. Some patients experience swelling of the lower extremities. Elevated liver enzymes have been reported in rare cases. The medication may lead to fluid retention causing weight gain. Headaches sometimes become more severe when blood pressure drops. Muscle spasms can occur as an uncommon adverse reaction.