Harvoni is a fixed-dose combination tablet containing sofosbuvir and velpatasvir. It is used to treat chronic hepatitis c infection in adults. The drug works by targeting the viral rna-dependent rna polymerase and the ns5a replication complex. Sofosbuvir inhibits the polymerase, preventing rna synthesis, while velpatasvir blocks the ns5a protein to halt viral replication. This dual inhibition leads to rapid suppression of hepatitis c virus rna levels in the bloodstream. The combined effect clears the infection and reduces liver inflammation without the need for interferon.

Harvoni is a fixed-dose combination tablet that contains the antiviral drugs sofosbuvir and ledipasvir and is prescribed for the treatment of chronic hepatitis c infection. Sofosbuvir works by inhibiting the viral rna polymerase enzyme, preventing the virus from replicating its genome. Ledipasvir blocks the viral ns5a protein, which is essential for the assembly of new virus particles and for maintaining viral replication complexes. Together the two agents target different steps of the hepatitis c life cycle, leading to a synergistic suppression of viral rna synthesis and particle formation. This dual inhibition reduces the amount of virus in the bloodstream, allowing the immune system and liver tissue to recover and reducing the risk of long-term liver damage. The overall effect is a high rate of sustained virologic response, meaning the virus remains undetectable after completing the prescribed course of therapy.

Hepatitis c treatment with Harvoni can cause fatigue in some individuals. Headache is reported as a common side effect among patients. Nausea and gastrointestinal discomfort may occur during therapy. Skin reactions such as rash or itching can develop in certain cases. Elevated liver enzymes have been observed in a minority of treated patients. These effects are generally mild and often resolve without intervention.

Harvoni is a prescription medication used to treat hepatitis c. Common side effects reported include fatigue and headache. Nausea and reduced appetite are also frequently mentioned. Sleep disturbances such as insomnia may happen. Skin reactions like rash or itching can develop. Laboratory changes including elevated liver enzymes are sometimes observed.