Anafranil is the brand name for the tricyclic antidepressant imipramine used to treat major depressive disorder. The drug functions by inhibiting the reuptake of norepinephrine and serotonin in the central nervous system, thereby increasing the levels of these neurotransmitters. This blockade leads to enhanced monoaminergic transmission which helps alleviate depressive symptoms. In addition to its antidepressant effect the medication can also reduce obsessive compulsive behaviors by modulating serotonergic activity. Pharmacodynamically the compound undergoes hepatic metabolism producing active metabolites that contribute to its long lasting therapeutic action. The overall mechanism involves alteration of synaptic catecholamine and serotonin concentrations resulting in improved mood regulation.

Anafranil is a tricyclic antidepressant that inhibits the reuptake of norepinephrine and serotonin. By blocking these transporters it increases synaptic concentrations of norepinephrine and serotonin. This dual action contributes to its antidepressant effect and also provides potent anti-obsessive activity. Clinically it is prescribed for major depressive disorder and obsessive-compulsive disorder. Its sedative properties arise from antagonism of histamine h1 receptors, which can lead to drowsiness. The medication also possesses strong anticholinergic effects that can produce dry mouth and constipation.

Drowsiness is a commonly reported side effect of Anafranil. Dizziness may occur especially during the initial adjustment period. Dry mouth can be bothersome but is usually mild. Constipation is another frequent complaint among users. Weight gain has been observed in some patients over time. Sweating may increase unexpectedly and affect comfort levels.

Anafranil may cause a dry feeling in the mouth. Some people notice constipation as a side effect. Dizziness or a light-headed sensation can occur. Drowsiness is also reported by many users. Excessive sweating can be observed during treatment. Some individuals experience weight gain while taking the medication. Blurred vision may happen occasionally. Changes in sexual desire or function are sometimes noted.